
Praeruptorin B(b)
CAS No. 73069-28-0
Praeruptorin B(b) ( Praeruptorin D )
产品货号. M21468 CAS No. 73069-28-0
Praeruptorin B 是甾醇调节元件结合蛋白 (SREBP) 的抑制剂。它还可以通过 PXR 介导的途径显着上调 CYP3A4 的表达和活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1402 | 有现货 |
![]() ![]() |
10MG | ¥2223 | 有现货 |
![]() ![]() |
25MG | ¥4410 | 有现货 |
![]() ![]() |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称Praeruptorin B(b)
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Praeruptorin B 是甾醇调节元件结合蛋白 (SREBP) 的抑制剂。它还可以通过 PXR 介导的途径显着上调 CYP3A4 的表达和活性。
-
产品描述Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.
-
体外实验Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9.
-
体内实验The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B.
-
同义词Praeruptorin D
-
通路Others
-
靶点Other Targets
-
受体SREBPs
-
研究领域——
-
适应症——
化学信息
-
CAS Number73069-28-0
-
分子量426.5
-
分子式C24H26O7
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 25 mg/mL (58.62 mM)
-
SMILESC\C=C(\C)C(=O)O[C@@H]1[C@H](OC(=O)C(\C)=C/C)C(C)(C)Oc2ccc3ccc(=O)oc3c12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Zu-Guo Zheng et al. Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. RSC Adv. 2018 8 354–366
产品手册




关联产品
-
Transportan
Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine.
-
DFP00173
DFP00173 是一种有效的选择性水通道蛋白 3 (AQP3) 抑制剂。 DFP00173 抑制小鼠和人类 AQP3,IC50 约为 0.1-0.4 μM。
-
6-Hydroxyindole
6-Hydroxyindole 是一种反应物,用于不对称合成 notoamide J(作为异戊二烯化吲哚生物碱的潜在生物合成前体),以及用于制备作为过氧化物酶体增殖物激活受体激动剂的吲哚氧乙酸衍生物。