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Praeruptorin B(b)

CAS No. 73069-28-0

Praeruptorin B(b) ( Praeruptorin D )

产品货号. M21468 CAS No. 73069-28-0

Praeruptorin B 是甾醇调节元件结合蛋白 (SREBP) 的抑制剂。它还可以通过 PXR 介导的途径显着上调 CYP3A4 的表达和活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1402 有现货
10MG ¥2223 有现货
25MG ¥4410 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Praeruptorin B(b)
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Praeruptorin B 是甾醇调节元件结合蛋白 (SREBP) 的抑制剂。它还可以通过 PXR 介导的途径显着上调 CYP3A4 的表达和活性。
  • 产品描述
    Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.
  • 体外实验
    Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9.
  • 体内实验
    The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B.
  • 同义词
    Praeruptorin D
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    SREBPs
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    73069-28-0
  • 分子量
    426.5
  • 分子式
    C24H26O7
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 25 mg/mL (58.62 mM)
  • SMILES
    C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(=O)C(\C)=C/C)C(C)(C)Oc2ccc3ccc(=O)oc3c12
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Zu-Guo Zheng et al. Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. RSC Adv. 2018 8 354–366
产品手册
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